Research Outreach: Mourad Ferdaoussi, "Spatiotemporal Pathways Regulating Insulin Secretion"

Thanks to this grant, Mourad Ferdaoussi and his research team will carry out work to understand how the pancreatic beta cell functions under normal conditions, in order to identify the disturbed mechanisms that lead to its dysfunction and death during the development of diabetes.

"We have already identified a new harmful mechanism that is amplified by diabetogenic stress factors. Our challenge is to deepen our understanding of this mechanism to better understand how it damages pancreatic beta cells and to design potential therapies targeting this mechanism in order to protect these cells. Our ultimate goal is to use our discoveries to develop effective treatment strategies for people at risk of or already suffering from diabetes."

Project Title: Spatiotemporal Pathways Regulating Insulin Secretion Research Program: Fundamental Insights into GPx4-Dependent Redox Regulation
Amount: 185 000$
Project Duration: 5 years
Funding Agency: Natural Sciences and Engineering Research Council of Canada (NSERC)