Nicolas Touret

Research:

The laboratory is focused on elucidating the molecular mechanisms involved in the initiation of immune responses when the organism is challenged with pathogens. We are using new imaging technologies, capable of resolving the behaviour of single molecules, to define the change of state overtime that receptors of innate immune cells (macrophages and dendritic cells) are undergoing during their interaction with pathogen's molecules.

Selected Publications:

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression.
Wang H, Wei E, Quiroga AD, Sun X, Touret N.
Lehner R. Mol Biol Cell. (2010) Jun 15; 21(12):1991-2000.

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.
Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S.
J Cell Biol. (2010) Feb 22; 188(4):547-63.

In situ measurement of the electrical potential across the phagosomal membrane using FRET and its contribution to the proton-motive force.
Steinberg BE, Touret N, Vargas-Caballero M, Grinstein S.
PNAS. (2007) May 29;104(22):9523-8.

Visualization of Vacuolar Acidification-induced Transcription of Genes of Pathogens inside Macrophages.
Martin-Orozco N, Touret N, Zaharik ML, Park E, Kopelman R, Miller S, Finlay BB, Gros P, Grinstein S.
Mol Biol Cell. (2006) Jan;17(1):498-510.

Quantitative and dynamic assessment of the contribution of the endoplasmic reticulum to phagosome formation.
Touret N, Paroutis P, Terebiznik M, Harrison R, Trombetta S, Pypaert M, Chow A, Jiang A, Shaw J, Yip C, Moore HP, van der Wel N, Houben D, J. Peters PJ, de Chastellier C, Mellman I and Grinstein S.
Cell. (2005) Oct 7;123(1):157-70.