Faculty
Targeting the autotaxin-lysophosphatidate-inflammatory axis to improve cancer treatment
Structure and function of macromolecules involved in bioenergetic processes
Discovery of Novel Functions of small RNAs
Biology of matrix metalloproteinases (MMPs) in health and disease
Regulation of intracellular pH via the Na+/H+ exchanger
Mechanisms of regulation of gene expression
Investigating mammary gland biology and breast cancer
Regulation of protein phosphatases and phosphorylation
Functional proteomics and protease biology
Structural studies of membrane proteins associated with disease states
Chemical and biochemical mechanisms of RNA processing
Endoplasmic reticulum in health and disease
Deciphering the functional architecture of molecular chaperone networks
Investigating how biomechanical forces alter cell behavior
Structural biology of signaling and trafficking
Structure and function of proteins involved in the protein ubiquitination pathway
Mechanisms of regulation of cell division
Molecular Cell Biology of Innate Immune Receptors
Structural investigations of infectious prions and other misfolded proteins
Regulation of calcium transport in heart disease
(1) Developing solution NMR for large protein complexes and membrane proteins.
(2)Targeting the cardiac troponin complex to understand and treat heart failure.
(2)Targeting the cardiac troponin complex to understand and treat heart failure.
Functional genomics and proteomics focused on post-translational modification (PTM)-mediated cell signaling
Regulation of cholesterol homeostasis
Structure, function and dynamics of muscle, prion, membrane, and antifreeze proteins
Chris Bleackley
Mechanisms of cell-mediated cytotoxicity and apoptosis
Joseph Casey
Membrane Transport in Corneal Blindness
Michael Ellison
Mechanisms of cellular regulation
Michael James
Three-dimensional structure of proteins; hydrolytic mechanisms of proteinases
Cyril Kay
Muscle contraction/relaxation: Protein de novo design
Ronald MacElhaney
Roles of lipids in the structure and function of biological membranes
Michael Schultz
Metabolic programming in vertebrate cells
Paul Scott
Structure and function of extracellular matrix macromolecules
Jim Stone
Neoplastic transformation of cultured cells by dominant oncogenes
Dennis Vance
Molecular and cell biology of phospholipid biosynthesis and function
Joel Weiner
Membrane protein structure and bioenergetics