Interventions

All enrolled patients will receive an active run-in period of standard dose-intensity of up to 24 hours to ensure initial metabolic and azotemic stabilization.

 Experimental Arm:
The experimental arm will be allocated to lower CRRT dose-intensity, defined as a delivered effluent flow rate of 10-15 mL/kg/hr. The rationale for this lower dose-intensity is based on the observed lower threshold of dose-intensity currently delivered in clinical practice and observational data showing this threshold is acceptable, tolerated and safe.

 Control Arm:
The control arm will be guideline-directed standard CRRT dose-intensity, defined as delivered effluent flow rate of 25-30 mL/kg/hr. The standard dose-intensity is aligned with current practice and by recommendations from international CPGs.