Eligibility and Criteria

Inclusion criteria:

i) age ≥ 18 years
ii) patient weight ≥ 55 kg

iii) plan to initiate CRRT or within 24 hours of having started CRRT for acute kidney injury (AKI), defined by fulfillment of the KDIGO consensus definition
iv) expected to survive and receive CRRT for a duration of ≥ 48 hours
v) able to consent or have an authorized representative consent after being informed on the details and risks of participation, unless a waiver or deferred consent process is approved by local REB.

 

Exclusion criteria:

i) indication for sustained higher dose-intensity CRRT (e.g., hyperammonemia in acute liver failure; hyperuricemia in tumor lysis syndrome; hyperkalemia in rhabdomyolysis)
ii) end-stage kidney disease receiving maintenance dialysis
iii) receipt of intermittent RRT for AKI during the current hospitalization
iv) inability to comply with the requirements of the study protocol.