Trial Endpoints

Primary outcome: All-cause mortality at 90 days.

Secondary outcomes:

1) RRT dependence at 90 days;

2) composite of death or RRT dependence at 90 days;

3) estimated glomerular filtration rate at 90 days;

4) albuminuria at 90 days;

5) major adverse kidney outcomes, defined as death, RRT dependence or eGFR < 75%="" baseline="" egfr="" at="" 90="" days;="">

6) ventilator-free days through day 28;

7) vasoactive therapy-free days through day 28;

8) ICU-free days through day 28;

9) hospitalization-free days through day 90;

10) death in ICU, at 28 days, and in-hospital;

11) health-related quality-of-life (EuroQoL EQ-5D-5L) at day 90 and at 1 year;

12) health care costs through 1 year;

13) vital status and RRT dependence at 1-year.