Patrick E MacDonald

1. Stožer A, Šterk M, Paradiž Leitgeb E, Markovič R, Skelin Klemen M, Ellis CE, Križančić Bombek L, Dolenšek J, MacDonald PE, Gosak M (2022) From isles of Königsberg to islets of Langerhans: Examining the Function of the endocrine pancreas through network science. Front Endocrinol, 13:922640.

2. Dafoe TJ, Dos Santos T, Spigelman AF, Lyon J, Smith N, Bautista A, MacDonald PE, Manning Fox JE (2022) Impacts of the COVID-19 pandemic on a human research islet program. Islets, 14(1):101-113.

3. Dai XQ, Camunas-Soler J, Briant LJB, dos Santos T, Spigelman AF, Walker EM, Arrojo e Drigo R, Bautista A, Jones RC, Lyon J, Nie A, Smith N, Manning Fox JE, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE* (2022) Heterogenous impairment of a-cell function in type 2 diabetes is linked to cell maturation state. Cell Metab, in press (bioRxiv: doi.org/10.1101/2021.04.08.435504)

4. Lin H, Smith N, Spigelman AF, Suzuki K, Ferdaoussi M, Jin Y, Bautista A, Wang YW, Manning Fox JE, Buteau J, MacDonald PE* (2021) β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice. Diabetes, 70(11):2626-2638.

5. Camunas-Soler J, Dai XQ# Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE* (2020) Patch-seq links single-cell transcriptomes to human islet dysfunction in diabetes. Cell Metabolism, 31(5):1017-1031.e4.

6. Ferdaoussi M, Smith N, Lin H, Bautista A, Spigelman AF, Lyon J, Dai X, Manning Fox JE, MacDonald PE* (2020) Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion. Physiological Reports, 8(8):e14420.

7. Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE* (2019) A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiological Reports, 7(19):e14250.

8. Fu J, Githaka JM, Dai XQ, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Manning Fox JE, Gaisano HY, MacDonald PE* (2019) A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes. JCI Insight, 14;5. pii: 127896.

9. Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL (2018) Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells. Nature Genetics. 50(8):1122-1131

10. Fu J, Dai XQ, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE* (2017) Kv2.1 clustering contributes to insulin exocytosis and rescues human β-cell dysfunction. Diabetes, 66(7):1890-1900.