Cores
SPP-ARC EXPERTISE CORES
In addition to supporting our researchers through funding of individuals projects, our consortium includes several large-scale research groups that aim to build capacity in pandemic preparedness research and to complement existing projects and infrastructure.
Molecular Virology Core
Core Lead: Tom Hobman
Team: Matthew Croxen, David Evans, Robert Ingham, Olivier Julien, Katharine Magor, David Marchant, Ryan Noyce, Vanessa Meier-Stephenson, Lorne Tyrrell
The goal of the Molecular Virology Core is to provide expertise and support for discovery, testing and validation of novel antiviral compounds and vaccine candidates at the University of Alberta. The core’s principal investigators, their trainees, and research staff have extensive expertise in isolation and characterization of respiratory and vector-borne viruses as well as developing methods and assays to identify antiviral compounds and support testing of novel vaccines that inhibit replication of these pathogens. Respiratory viruses that are routinely studied by this group include coronaviruses, influenza viruses, pneumoviruses, picornaviruses and poxviruses.
Therapeutics Core
Core Lead: Matthias Götte
Team: Kalyan Das, Dennis Hall, Tom Hobman, Olivier Julien, John Klassen, Joanne Lemieux, Katharine Magor, David Marchant, Michael Meanwell, Vanessa Meier-Stephenson, Ryan Noyce, John Vederas, Frederick West
The therapeutic arm of SPP-ARC’s efforts in the coming years will focus on two principal targets, viral RNA-dependent RNA polymerases (RdRp) and proteases. The supported projects are designed to balance capacity building and innovation in the areas of enzymology, structure-based drug design, medicinal chemistry and analytical chemistry. Success with the proposed research will facilitate rapid responses to emerging viruses with the overarching goal to advance small molecule antivirals more rapidly into clinical trials.
Vaccine & Immune Responses Core
Core Lead: Troy Baldwin
Team: Xavier Clemente-Casares, Edan Foley, Kevin Kane, Matt Macauley, David Marchant, Ryan Noyce, Hanne Ostergaard, Maya Shmulevitz, Sue Tsai, Lorne Tyrrell, Harrisios Vliagoftis, Holger Wille, Stephanie Yanow
The SPP-ARC Vaccine & Immune Responses Core comprises a diverse group of experts in vaccinology, virology, immunology, glycan chemistry, protein biochemistry and machine learning. Together we will create a variety of vaccine candidates and determine the effects of different vaccine platforms, antigens, adjuvants, and administration routes on specific aspects of immune responses, pathogen control, and possible adverse effects. This will be the first of its kind, side-by-side biological comparison of how distinct viral, nucleic acid and protein vaccine platforms delivering the same antigens and administered intranasally versus intramuscularly into healthy male and female mice affect vaccine efficacy. A wide spectrum of parameters will be measured including rarely- assessed changes to specific innate, humoral, and cellular immunity, formation of systemic and tissue resident long-term memory cell populations, a multitude of potential adverse pathologies in all organs, and most importantly pathogen control. We will concurrently establish assays for monitoring immune responses using preserved human samples to allow rapid transition to human applications. Collectively, this study will generate new knowledge regarding different vaccine approaches and increase capacity for development and testing of vaccines thereby preparing us to combat future pandemics.
Clinical Samples Core
Core Lead: Lorne Tyrrell
Team: Xavier Clementes-Casares, Matthew Croxen, Kalyan Das, Mathew Diggle, Matthias Götte, Olivier Julien, Katharine Magor, David Marchant, Vanessa Meier-Stephenson, Michael Mengel, Xiaoli Pang, Lawrence Richer, Bruce Ritchie, Michael Serpe, Graham Tipples, Karina Top, Greg Tyrrell
As coronaviruses and other respiratory viruses become endemic in our population, with new strains emerging in outbreaks and new pathogens evolve, establishing a workflow to access real-time samples sufficient to provide robust data and making such studies feasible to answer many scientific questions is a key component of pandemic preparedness. Having a system ahead of time will facilitate a rapid response in the setting of a pandemic or an outbreak. The Clinical Samples core will establish a framework to enable the collection, storage and sharing of biosamples and their derivatives, such as virus isolates, plasmids, etc., as well as the relevant clinical data.