High-throughput with particle technology for toxicology and materials discovery

Lutz Mädler
University of Bremen, Faculty of Production Engineering, and Leibniz Institute for Materials Engineering IWT

3:30pm - February 14, 2019 - CCIS L2 190

Abstract:

High-throughput screening is a well-established method for scientific experimentation in chemistry and biology. Examples are heterogeneous catalysts, drug developments and nanoparticle toxicology. These methods involve the synthesis of small sample volumes often in form of particles that are quickly tested. The tests are designed to quickly obtain easily accessible data (called descriptors) that are related with a predictor function to the desired properties. One particle based high-throughput concept for the evaluation of potential toxicological hazards will be introduced. Furthermore, a new concept is presented which transfers high-throughput screening to the exploration of structural metals. The method comprises the synthesis of alloy samples in form of particles. The samples obtain a defined microstructure by fast or parallel thermal and mechanical treatments and are subsequently subjected to fast descriptor tests while a mathematical algorithm develops the predictor function.