Drug discovery puts PhD grad on the leading edge of medical science

Yasser Tabana’s experiences developing an immune-boosting drug to fight cancer set him up for success as a postdoc working on a blood test to diagnose autoimmune diseases.

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For PhD grad Yasser Tabana, working with world-leading researchers at the U of A is the fulfilment of a dream that took him from his small hometown in Syria to Malaysia and Canada. (Photo: John Ulan)

In 2013, Yasser Tabana was displaced from his small town in the countryside of Damascus because of war and instability in Syria. 

“The war in Syria affected everyone,” says Tabana. 

“It was not easy; I had a lot of friends studying together in the pharmacy faculty (at Arab International University) in Syria. I don’t know if they are still alive or not.”

Tabana shared a dream with his classmates of studying and gaining international research experience. To fulfil his dream, Tabana moved to Malaysia to pursue a master’s degree in pharmaceutical sciences before arriving in Canada, where he completed a PhD in the Faculty of Pharmacy & Pharmaceutical Sciences at the University of Alberta. 

“There were many challenges, but I acquired essential knowledge, and these experiences have shaped who I am today.”

While studying under the supervision of Khaled Barakat, Tabana was a part of a larger collaborative U of A team that focused on research to develop a small molecule in the form of a drug that engages with the human immune system to fight cancer and viral diseases.

“We’re not targeting cancer cells themselves,” says Tabana. “We’re trying to mobilize the immune system where cells can actually fight the cancer.”

The drug would be inexpensive and easy to synthesize, unlike current immune system medications on the market.

PhD grad Yasser Tabana examines a sample through a microscope in the lab. (Photo: John Ulan)
While earning his PhD, Yasser Tabana worked with a team developing a small-molecule drug that engages the immune system to fight cancer cells. (Photo: John Ulan)

Currently, as a postdoctoral researcher, Tabana is working in the Department of Biochemistry in the Faculty of Medicine & Dentistry under the supervision of Richard Fahlman to develop a blood test for diagnosing autoimmune diseases.

“Our team has identified certain biomarkers in patients with myasthenia gravis and is currently working on identifying biomarkers for rheumatoid arthritis and multiple sclerosis,” says Tabana.

Testing for these protein biomarkers will help clinicians identify sick patients while avoiding time-intensive diagnostic methods.

“There is great potential in this project,” says Tabana. “A good diagnosis is the first step to better serve our patients.”

“I’m very grateful for the University of Alberta. The knowledge and experience I have gained, and continue to gain, are remarkable.”

Yasser Tabana

Yasser Tabana
(Photo: John Ulan)

In addition to being a dedicated researcher, Tabana is also a passionate educator. He taught undergraduate pharmacy students and was appointed as a teaching fellow at the U of A’s Peter Lougheed Leadership College, where he was introduced to experiential learning, effective teaching approaches and aspects of adaptive leadership.

“I’m very grateful for the University of Alberta,” he says. “The knowledge and experience I have gained, and continue to gain, are remarkable.”

In particular, Tabana credits Barakat for the “amazing mentorship” he experienced during his PhD studies. 

“He always encouraged me to attend conferences, join workshops, do volunteer work and grow not just as a scientist, but as a well-rounded individual.”

Tabana has received multiple awards and scholarships, including the Alberta Innovates Scholarship, Graduate Students’ Association Recognition Award, Antoine Noujaim Graduate Scholarship, Shire Canada Inc. Graduate Award, Teaching Fellow Training Award and Alberta Graduate Excellence Scholarship.