Royal Alexandra Hospital Critical Care Research and Quality Assurance Group
Royal Alexandra Hospital Critical Care Research and Quality Assurance Group
Site Lead Investigator: Dr. J Kutsogiannis
Research Contacts: Pat Thompson & Tayne Hewer
Office: 780-735-4096
About the site:
The General Systems Unit at the Royal Alexandra Hospital is a 30-bed adult intensive care unit located in an inner city teaching hospital. The clinical research group has a rich history of nearly 30 years, actively participating in academic investigator-initiated, CIHR, and industry-funded clinical trials and cohort studies.
Our research focuses on specialized areas such as sepsis, renal replacement therapy, substance use disorder, respiratory failure, pneumonia and ARDS as it relates to mechanical ventilation, enteral and parenteral nutrition, end of life care and family satisfaction with care, as well as providing support to other researchers within the Royal Alexandra Hospital, including trauma, spine, and thoracic surgery.
| Theme | Current Project | Invesitgator |
| Infectious Disease | A Multicentre Concealed‐Allocation Parallel‐Group Blinded Randomized Controlled Trial to Ascertain the Effect of High‐Dose Intravenous Vitamin C Compared to Placebo on Mortality or Persistent Organ Dysfunction at 28 Days in Septic Intensive Care Unit Patients (LOVIT PROPER) | Dr. J Kutsogiannis |
| Infectious Disease | A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Adjunctive Recombinant Human Plasma Gelsolin with Standard of Care For Moderate-To-Severe Ards Due To Pneumonia or Other Infections | Dr. J Kutsogiannis |
| Critical Care Nephrology | Continuous Renal Replacement Therapy Protocol: CRRTnet A Multicenter Data Registry for Outcomes for Continuous Renal Replacement Therapy | Dr. S Bagshaw Dr. O Rewa |
| Critical Care Nephrology | Dialyzing Wisely | Dr. O Rewa |
| Neurosciences | First-In-Human Study of Ak1320 Encapsulated Microspheres (Ak1320 Ms) In Subjects with Degenerative Spondylolisthesis and Concomitant Symptomatic Spinal Stenosis Who Are Undergoing Decompression and Single Level Instrumented Posterolateral Lumbar Autograft Fusion Surgery | Dr. Fox Dr. J Kutsogiannis |
| Infectious Disease | Lessening Organ Dysfunction with VITamin C; A Multicentre Concealed-Allocation Parallel-Group Blinded Randomized Controlled Trial to Ascertain the Effect of High-Dose Intravenous Vitamin C Compared to Placebo on Mortality or Persistent Organ Dysfunction at 28 Days in Hospitalized Patients with COVID-19 (Lovit-Covid) | Dr. J Kutsogiannis |
| Respiratory Sciences | Liberation from Mechanical Ventilation in Spinal Cord Injury: A national cohort study | Dr. J Kutsogiannis |
| Respiratory Sciences | Liberation from mechanical ventilation using Extubation Advisor Decision Support: The multicentre (LEADS) Pilot Trial | Dr. J Kutsogiannis |
| Neurosciences | Nimodipine Pharmacokinetic Variability and its Impact on Outcomes in Patients with Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Study (Nimodipine) |
Dr. J Kutsogiannis |
| Neurosciences | PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury, a double-blind Randomized Controlled Trial (PROTEST) | Dr. J Kutsogiannis Dr. O'Kelly |
| Critical Care Nephrology |
QUALITY CRRT | Dr. O Rewa |
| Infectious Disease | Randomized, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia (REMAP-CAP) | Dr. J Kutsogiannis Dr. W Sligl |
| Perioperative Medicine | Relaxation for Critically ill Patient Outcomes and Stress Coping Enhancement (REPOSE): Pilot Clinical trial of an integrative intervention to improve adult critically ill patients’ delirium and related outcomes. |
E Papathanassoglou |
| Respiratory Sciences | The Frequency of Screening and SBT Technique Trial: The FAST Trial A North American Weaning Collaboration (FAST) | Dr. J Kutsogiannis |
| Health Services Research | The incidence and clinical outcomes of patients with substance use disorders admitted to intensive care: SUD | Dr. J Kutsogiannis |
| Respiratory Sciences | The measurement of Cough Peak Flows to predict liberation from mechanical ventilation or tracheostomy in respiratory and neurological subgroups of critically ill patients (CPF) | Dr. J Kutsogiannis |
| Neurosciences | The New Edmonton Cervical Spine Board: (NECs Board) Trial | Dr. Fox Dr. J Kutsogiannis |
| Respiratory Sciences | The Use of Capnographic Late Dead Space Fraction and Clinical Prediction Rules in the Prediction of Pulmonary Embolism in Critically Ill Patients Undergoing Computed Tomography of the Chest or Ventilation Perfusion Scanning (Deadspace) | Dr. J Kutsogiannis |